Turns pass clockwise, and every turn is the same three phases in order: 4 actions → draw 2 → infect.
1. Take 4 actions (any mix, repeats allowed):
- Drive/ferry — move along a line on the map.
- Direct flight — discard a city card to fly to that city.
- Charter flight — discard the card matching the city you're standing in to fly anywhere.
- Shuttle flight — hop between any two research stations.
- Build a research station — discard the card matching your current city.
- Treat disease — remove 1 cube here (or all cubes of a cured color, in one action).
- Share knowledge — give or take a card while you and a teammate are both in the city that card names.
- Discover a cure — at a research station, discard 5 cards of one color to cure that disease.
2. Draw 2 player cards. Hand limit is 7. Draw an Epidemic and resolve it immediately: increase the infection rate one step, infect by taking the bottom infection card and dropping 3 cubes there, then intensify by shuffling the infection discard pile and placing it back on top of the deck. That last step is the cruel one — every city already infected this game is now queued to be hit again.
3. Infect cities. Flip infection cards equal to the current infection rate and add 1 matching cube to each city named. A city that would take a 4th cube of a color outbreaks instead: no cube there, but one cube to every connected city, and the outbreaks marker climbs. Chain outbreaks are how teams die.
A turn, played out. Ana (Researcher) is in Cairo holding three black cards, and Beto (Scientist) holds two more. Cairo has 3 black cubes and Khartoum next door has 2 — one bad flip from a chain. Ana's four actions: treat Cairo twice (down to 1 cube — the outbreak risk is gone), then drive to Khartoum and treat once. Beto flies to Cairo next turn, Ana uses her role to hand him all three black cards from anywhere in the city, and with five in hand he shuttles to Atlanta and cures black. The lesson: cure cards live in one hand, so the whole team's job is getting them there before the board burns.